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With respect to VHE, Verrotti and coworkers [69] demonstrated an increase in glutamine production in astrocytes whereas glutamine release was inhibited

Notably, Magel2 -null mice were found to be hyperresponsive to setmelanotide compared to wild-type controls, indicating exogenous agonists are more effective in conditions with impaired MC agonist production and downstream signaling (81)

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